English Name: Alexander Birbrair

研究兴趣：分子生物学、医学与健康科学、干细胞生物学

他在威斯康辛麦迪逊的实验室致力于了解病理条件下生物系统受损和失效的机制，重点是预防或逆转这些有害过程。我们的研究重点是不同组织微环境中的组织干细胞、血管和外周神经系统。我们对研究导致细胞在发育、生命和疾病过程中行为变化的机制很感兴趣。了解这些机制如何在癌症中受到影响将有助于开发新型疗法的靶点。为此，我们利用最先进的技术，包括双光子显微镜和共聚焦显微镜、体内系谱追踪方法、FACS分选、单细胞RNA测序、器官、组织和细胞移植、神经回路分析，以及结合癌症小鼠模型的复杂Cre/loxP技术。因此，我们的最终目标是为癌症治疗确定新的潜在细胞和分子靶点。

Selected Publications

(1) Costa PAC, Silva WN, Prazeres PHDM, Picoli CC, Guardia GDA, Costa AC, Oliveira MA, Guimarães PPG, Gonçalves R, Pinto MCX, Amorim JH, Azevedo VAC, Russo RC, Resende RR, Cunha TM, Galante PAF, Mintz A, Birbrair A. (2021) Chemogenetic modulation of sensory neurons reveals their regulating role in melanoma progression. Acta Neuropathologica Communications. 9(1):183. doi: 10.1186/s40478-021-01273-9. PMID: 34784974.

(2) Picoli CC, Gonçalves BÔP, Santos GSP, Rocha BGS, Costa AC, Resende RR, Birbrair A. (2021) Pericytes cross-talks within the tumor microenvironment. Biochimica et Biophysica Acta – Reviews on Cancer. 1876(2):188608. doi: 10.1016/j.bbcan.2021.188608. PMID: 34384850.

(3) Sena IFG, Rocha BGS, Picoli CC, Santos GSP, Costa AC, Gonçalves BOP, Garcia APV, Soltani-Asl M, Coimbra-Campos LMC, Silva WN, Costa PAC, Pinto MCX, Amorim JH, Azevedo VAC, Resende RR, Heller D, Cassali GD, Mintz A, Birbrair A. (2021) C(3)1-TAg in C57BL/6J background as a model to study mammary tumor development. Histochemistry and Cell Biology. In press. doi: https://doi.org/10.1007/s00418-021-01995-w. PMID: 34003355.

(4) Nobre AR, Risson E, Singh DK, Martino JD, Cheung JF, Wang J, Johnson J, Russnes HG, Bravo-Cordero JJ, Birbrair A, Naume B, Azhar M, Frenette PS, Aguirre-Ghiso JA. (2021) Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF-β2. Nature Cancer. 2:327–339. doi: 10.1038/s43018-021-00179-8. PMID: 34993493.

(5) Prazeres PHDM, Leonel C, Silva WN, Rocha BGS, Santos GSP, Costa AC, Picoli CC, Sena I, Gonçalves WA, Vieira MS, Costa PAC, Campos LMCC, Paz MT, Costa MR, Resende RR, Cunha TM, Mintz A, Birbrair A. (2020) Ablation of sensory nerves favours melanoma progression. Journal of Cellular and Molecular Medicine. 24(17):9574-9589. PMID: 32691511.

(6) Paiva AE, Lousado L, Guerra DAP, Azevedo PO, Sena IFG, Andreotti JP, Santos GSP, Gonçalves R, Mintz A, Birbrair A. (2018) Pericytes in the Premetastatic Niche. Cancer Research. Review. 78(11):2779-2786. PMID: 29789421.

(7) Birbrair A, Sattiraju A, Zhu D, Zulato G, Batista I, Nguyen VT, Messi ML, Solingapuram Sai KK, Marini FC, Delbono O, Mintz A. (2017) Novel Peripherally Derived Neural-Like Stem Cells as Therapeutic Carriers for Treating Glioblastomas. Stem Cells Translational Medicine. 6(2):471-481. PMID: 28191774.

(8) Asada N, Kunisaki Y, Pierce H, Wang Z, Fernandez NF, Birbrair A, Ma’ayan A, Frenette PS. (2017) Differential cytokine contributions of perivascular haematopoietic stem cell niches. Nature Cell Biology. 19(3):214-223. PMID: 28218906.

(9) Khan JA, Mendelson A, Kunisaki Y, Birbrair A, Kou Y, Arnal A, Pinho S, Ciero P, Nakahara F, Ma’ayan A, Bergman A, Merad M and Frenette PS. (2015) Identification of a portal vessel-associated fetal liver hematopoietic stem cell niche. Science. 351:176-180. PMID: 26634440.

(10) Birbrair A, Zhang T, Wang ZM, Messi ML, Olson JD, Mintz A and Delbono O. (2014). Type-2 Pericytes Participate in Normal and Tumoral Angiogenesis. American Journal of Physiology-Cell Physiology. 307 (1): C25-C38. PMID: 24788248.

外部链接

威斯康星大学 麦迪逊分校官网

birbrair_cv_062622a.pdf